Tubulin Protein At A Glance

  • highly conserved superfamily of cytoskeletal proteins
  • alpha and beta tubulin heterodimers polymerize into microtubules, a major component of the cytoskeleton
  • nucleation primarily occurs at the centrosome and other microtubule organizing centers (MTOCs)
  • inherent GTPase activity drives microtubule dynamic instability
  • substrate for kinesin and dynein motor proteins important for intracellular transport
  • primary structural component of the mitotic spindle, cilia, and flagella
  • essential for cell morphology, mitosis, meiosis, and other cellular functions
  • tubulin mutations cause tubulinopathy and neuronal disorders
  • target of cell cycle inhibitors including paclitaxel, vinblastine, nocodazole, colchicine, and combretastatin

Full Star RawFull Star - YellowFull Star - YellowFull Star - Yellow0.8 star - Yellow   Customer Satisfaction Rating  4.8 out of 5 stars

 

“The Cycled Tubulin from PurSolutions is qualitatively as good as the one that we make in the lab. It is usable for live polymerization assay. To our knowledge, no other company managed to achieve this before and we can definitely recommend it!”

Full Star RawFull Star - YellowFull Star - YellowFull Star - Yellow0.8 star - Yellow   Customer Satisfaction Rating  4.8 out of 5 stars

The (Ultra-Pure Actin) was good, slower polymerization kinetics than the too-fast Cytoskeleton Inc actin even without gel filtration. We'll order it again.”

Full Star RawFull Star - YellowFull Star - YellowFull Star - Yellow0.8 star - Yellow   Customer Satisfaction Rating  4.8 out of 5 stars

“Great solubility and clear labeling”

Cycled

Cycled Tubulin™ (>99%)

CYCLED TUBULIN™ (>99%)

Cycled Tubulin™ is isolated by cycling bovine brain homogenate through conditions that promote tubulin polymerization/depolymerization in high salt buffers. The resulting protein is >99% pure and cryopreserved at 20 mg/ml in 80 mM PIPES, 1 mM MgCl2, and 1 mM EGTA (pH 6.8).

Datasheet |

 

Our Best Seller!  The most Active and Soluble Tubulin Protein on the market:  $150/mg

Citations

Schimert KI, et al. Intracellular Cargo Transport By Single-Headed Kinesin Motors. PNAS. 2019. Link

Jiang, et al. Interplay between the Kinesin and Tubulin Mechanochemical Cycles Underlies Microtubule Tip Tracking by the Non-motile Ciliary Kinesin Kif7. Dev Cell. 2019. Link

Geyer EA. Mechanistic Analysis of Microtubule Dynamics and Regulation. UT Southwestern Dissertation. 2018. Link

Ross T, et al. Controlling Organization and Forces in Active Matter Through Optically-Defined Boundaries. BioRxiv. 2018. Link

Thawani A, et al. XMAP215 Is a Microtubule Nucleation Factor That Functions Synergistically with the γ-Tubulin Ring Complex. Nat Cell Biol. 2018. Link

And more...

Lyophilized
Alexa Fluor® 488
Alexa Fluor® 594
Alexa Fluor® 647
Cy5
Biotin-XX

Customer Satisfaction Rating  4.8 out of 5

The (Ultra-Pure Actin) was good, slower polymerization kinetics than the too-fast Cytoskeleton Inc actin even without gel filtration. We'll order it again.”

Customer Satisfaction Rating  4.8 out of 5

“Great solubility and clear labeling”

Customer Satisfaction Rating  4.8 out of 5

“The Cycled Tubulin from PurSolutions is qualitatively as good as the one that we make in the lab. It is usable for live polymerization assay. To our knowledge, no other company managed to achieve this before and we can definitely recommend it!”

  Some of our Customers

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Dana Farber Cancer Institute Logo
Mass General Logo
National Institute of Health Logo
Princeton University Logo
UT Southwestern Medical Center Logo

  Customers Include:

California Institute of Technology logo
Dana Farber Cancer Institute Logo
Mass General Logo
National Institute of Health Logo
Princeton University Logo
UT Southwestern Medical Center Logo

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