Tubulin Product

Tubulin Protein At A Glance

highly conserved superfamily of cytoskeletal proteins
alpha and beta tubulin heterodimers polymerize into microtubules, a major component of the cytoskeleton
nucleation primarily occurs at the centrosome and other microtubule organizing centers (MTOCs)
inherent GTPase activity drives microtubule dynamic instability
substrate for kinesin and dynein motor proteins important for intracellular transport
primary structural component of the mitotic spindle, cilia, and flagella
essential for cell morphology, mitosis, meiosis, and other cellular functions
tubulin mutations cause tubulinopathy and neuronal disorders
target of cell cycle inhibitors including paclitaxel, vinblastine, nocodazole, colchicine, and combretastatin

Customer Satisfaction Rating 4.8 out of 5 stars

“The Cycled Tubulin from PurSolutions is qualitatively as good as the one that we make in the lab. It is usable for live polymerization assay. To our knowledge, no other company managed to achieve this before and we can definitely recommend it!”

Customer Satisfaction Rating 4.8 out of 5 stars

“The (Ultra-Pure Actin) was good, slower polymerization kinetics than the too-fast Cytoskeleton Inc actin even without gel filtration. We'll order it again.”

Customer Satisfaction Rating 4.8 out of 5 stars

“Great solubility and clear labeling”

Cycled

Lyophilized

Alexa Fluor® 488

Alexa Fluor® 594

Alexa Fluor® 647

Cy5

Biotin-XX

Cycled

Cycled Tubulin™ (>99%)

Cycled Tubulin™ is isolated by cycling bovine brain homogenate through conditions that promote tubulin polymerization/depolymerization in high salt buffers. The resulting protein is >99% pure and cryopreserved at 20 mg/ml in 80 mM PIPES, 1 mM MgCl2, and 1 mM EGTA (pH 6.8).

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Our Best Seller! The most Active and Soluble Tubulin Protein on the market: $150/mg

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Citations

Schimert KI, et al. Intracellular Cargo Transport By Single-Headed Kinesin Motors. PNAS. 2019. Link

Jiang, et al. Interplay between the Kinesin and Tubulin Mechanochemical Cycles Underlies Microtubule Tip Tracking by the Non-motile Ciliary Kinesin Kif7. Dev Cell. 2019. Link

Geyer EA. Mechanistic Analysis of Microtubule Dynamics and Regulation. UT Southwestern Dissertation. 2018. Link

Ross T, et al. Controlling Organization and Forces in Active Matter Through Optically-Defined Boundaries. BioRxiv. 2018. Link

Thawani A, et al. XMAP215 Is a Microtubule Nucleation Factor That Functions Synergistically with the γ-Tubulin Ring Complex. Nat Cell Biol. 2018. Link

And more...

Lyophilized

Lyophilized Tubulin (>99%)

Lyophilized Tubulin is isolated by selective precipitation from bovine brain homogenate. The resulting protein is >99% pure and lyophilized. When reconstituted with ultrapure water to 40 mg/ml, the buffer conditions are 10 mM Sodium Phosphate, 0.5 mM MgCl2, 0.1 mM GTP, and 0.25 M Trehalose (pH 7.0).

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Stored and Shipped at Room Temperature: $105/mg

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Citations

Yao XQ, et al. Navigating the Conformational Landscape of G Protein-Coupled Receptor Kinases during Allosteric Activation. J Biol Chem. 2017. Link

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Alexa Fluor® 488

Labeled Tubulin-Alexa Fluor® 488

Labeled Tubulin-Alexa Fluor® 488 is generated by covalently linking the dye to random tubulin surface lysines in its polymerized form. The final product is cryopreserved at 20 mg/ml in 50 mM K-Glutamate and 0.5 mM MgCl2 (pH=7.0), and is commonly visualized with a FITC filter set with maximum excitation/emission wavelengths of 494/517 nm.

Datasheet |

The only green Alexa Fluor®-Labeled Tubulin Protein on the market: $295/0.1 mg

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Citations

Vemu A, et al. Severing Enzymes Amplify Microtubule Arrays through Lattice GTP-Tubulin Incorporation. Science. 2018. Link

And more...

Alexa Fluor® 594

Labeled Tubulin-Alexa Fluor® 594

Labeled Tubulin-Alexa Fluor® 594 is generated by covalently linking the dye to random tubulin surface lysines in its polymerized form. The final product is cryopreserved at 20 mg/ml in 50 mM K-Glutamate and 0.5 mM MgCl2 (pH=7.0), and is commonly visualized with a Texas Red filter set with maximum excitation/emission wavelengths of 590/617 nm.

Datasheet |

The only red Alexa Fluor®-Labeled Tubulin Protein on the market: $295/0.1 mg

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Alexa Fluor® 647

Labeled Tubulin-Alexa Fluor® 647

Labeled Tubulin-Alexa Fluor® 647 is generated by covalently linking the dye to random tubulin surface lysines in its polymerized form. The final product is cryopreserved at 20 mg/ml in 50 mM K-Glutamate and 0.5 mM MgCl2 (pH=7.0), and is commonly visualized with a Cy5 filter set with maximum excitation/emission wavelengths of 651/672 nm.

Datasheet |

The only far-red Alexa Fluor®-Labeled Tubulin Protein on the market: $295/0.1 mg

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Citations

Farhadi L, et al. Active Self-Organization of Actin-Microtubule Composite Self-Propelled Rods. Front Phys. 2018. Link

Ross T, et al. Controlling Organization and Forces in Active Matter Through Optically-Defined Boundaries. BioRxiv. 2018. Link

And more...

Cy5

Labeled Tubulin-Cy5

Labeled Tubulin-Cy5 is generated by covalently linking the dye to random tubulin surface lysines in its polymerized form. The final product is cryopreserved at 20 mg/ml in 50 mM K-Glutamate and 0.5 mM MgCl2 (pH=7.0), and is commonly visualized with a Cy5 filter set with maximum excitation/emission wavelengths of 649/67 nm.

Datasheet |

The only Cy5-Labeled Tubulin Protein on the market: $295/0.1 mg

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Biotin-XX

Labeled Tubulin-Biotin-XX

Labeled Tubulin-Biotin-XX is generated by covalently linking the biomolecule to random tubulin surface lysines in its polymerized form. The final product is cryopreserved at 20 mg/ml in 50 mM K-Glutamate and 0.5 mM MgCl2 (pH=7.0), and demonstrates an affinity toward streptavidin-coated beads and streptavidin-coated coverslips.

Datasheet |

Strong Affinity for Streptavidin: $295/0.1 mg

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Citations

Geyer EA. Mechanistic Analysis of Microtubule Dynamics and Regulation. UT Southwestern Dissertation. 2018. Link

And more...

Customer Satisfaction Rating 4.8 out of 5

“The (Ultra-Pure Actin) was good, slower polymerization kinetics than the too-fast Cytoskeleton Inc actin even without gel filtration. We'll order it again.”

Customer Satisfaction Rating 4.8 out of 5

“Great solubility and clear labeling”

Customer Satisfaction Rating 4.8 out of 5

“The Cycled Tubulin from PurSolutions is qualitatively as good as the one that we make in the lab. It is usable for live polymerization assay. To our knowledge, no other company managed to achieve this before and we can definitely recommend it!”

Tubulin Protein At A Glance

Customer Satisfaction Rating 4.8 out of 5 stars

Customer Satisfaction Rating 4.8 out of 5 stars

Customer Satisfaction Rating 4.8 out of 5 stars

Cycled Tubulin™ (>99%)

Our Best Seller! The most Active and Soluble Tubulin Protein on the market: $150/mg

Citations

Lyophilized Tubulin (>99%)

Stored and Shipped at Room Temperature: $105/mg

Citations

Labeled Tubulin-Alexa Fluor® 488

The only green Alexa Fluor®-Labeled Tubulin Protein on the market: $295/0.1 mg

Citations

Labeled Tubulin-Alexa Fluor® 594

The only red Alexa Fluor®-Labeled Tubulin Protein on the market: $295/0.1 mg

Labeled Tubulin-Alexa Fluor® 647

The only far-red Alexa Fluor®-Labeled Tubulin Protein on the market: $295/0.1 mg

Citations

Labeled Tubulin-Cy5

The only Cy5-Labeled Tubulin Protein on the market: $295/0.1 mg

Labeled Tubulin-Biotin-XX

Strong Affinity for Streptavidin: $295/0.1 mg

Citations

Customer Satisfaction Rating 4.8 out of 5

Customer Satisfaction Rating 4.8 out of 5

Customer Satisfaction Rating 4.8 out of 5

Some of our Customers

Customers Include:

Tubulin Protein At A Glance

Customer Satisfaction Rating 4.8 out of 5 stars

Customer Satisfaction Rating 4.8 out of 5 stars

Customer Satisfaction Rating 4.8 out of 5 stars

Cycled Tubulin™ (>99%)

Our Best Seller! The most Active and Soluble Tubulin Protein on the market: $150/mg

Citations

Customer Satisfaction Rating 4.8 out of 5

Customer Satisfaction Rating 4.8 out of 5

Customer Satisfaction Rating 4.8 out of 5

Some of our Customers

Customers Include:

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