Tubulin structure PurSolutions

Unlabeled Tubulin

Tubulin, a highly conserved cytoskeletal protein, is required for several essential eukaryotic processes including intracellular transport, intercellular signaling, extracellular sensing, cell migration, and cell division. Tubulin is a heterodimer of α- and β-tubulin, and polymerizes into higher order filaments termed microtubules (MTs). Given the asymmetry of tubulin dimers, MTs have inherent polarity with distinct “+” (β-tubulin exposed) and “-” (α-tubulin exposed) ends. Another critical feature of MTs is their dynamic instability, a consequence of the GTPase activity of tubulin. This property confers force-generating capabilities to MTs that are critical for cell division. For this reason, tubulin is a powerful target for the therapeutic intervention of neoplastic diseases such as cancers.

We offer two unlabeled tubulin products, Cycled Tubulin™ and Lyophilized Tubulin, to give you control over product quality and pricing.

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Labeled Tubulin

The microtubule (MT) network is a dynamic, force-generating cytoskeletal system essential for a number of basic cellular processes. MTs also serve as a track for kinesin and dynein motor proteins. As such, visualization of MTs in real time, both in cells and in vitro, is critical in understanding cellular function and human disease. Furthermore, immobilization of MTs onto solid surfaces such as glass coverslips and beads allows for the biophysical study of these molecular machines. Tubulin, the basic component of MTs, can be functionalized for such applications by covalent linkage with a fluorescent dye or biomolecule. Such modifications must be performed in a way that maintains tubulin polymerization competency and functionality. The resulting labeled tubulin is useful in a number of applications ranging from live cell injection/imaging to in vitro nanoscale devices.

We offer Alexa Fluor® labeled tubulin products with complementary spectroscopic properties for optimal visual performance. We also provide Biotin-XX labeled tubulin that demonstrates a strong affinity for streptavidin-coated surfaces.

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