Journal Club

Critical Research Updates in the Cytoskeleton Field

Journal Club – August 2020

WAVE-Deficient Autoimmune Disorders, Wandering Monopolar Spindles, and a Guide to Selecting Cellular Actin Probes

Journal Club Picks

  • Five patients with immunodeficiency harbor mutations in the WAVE regulatory complex.
    Cook et al.  | Lenardo Lab  |  Science
  • Dilution of the cell cycle inhibitor Rb in growing cells triggers cell division to maintain cell size.
    Zatulovskiy et al.  | Skotheim Lab  |  Science
  • Curved protofilaments at growing microtubule ends could explain kinetochore coupling.
    Gudimchuk  | McIntosh Lab  |  Nature Communications
  • Microtubules help coordinate cytokinetic furrow formation in fission yeast.
    Dundon and Pollard  | Pollard Lab  |  Molecular Biology of the Cell
  • Wandering monopolar spindles in flattened cells reveal spindle positioning mechanisms.
    Dimitracopoulos et al.  | Baum Lab |  Current Biology
  • XMAP215 and γ-tubulin have distinct modes of promoting microtubule nucleation.
    King et al.  | Davis Lab  |  Molecular Biology of the Cell
  • A pliable tethering domain confers functional diversity to the microtubule motor KIF14.
    Zhernov et al.  | Lansky Lab  |  Current Biology


Structural Insights into Actin Filament Recognition by Commonly Used Cellular Actin Markers

Kumari et al.  |  The EMBO Journal
High resolution structures of commonly utilized actin markers – Read


Disease Mutations in Striated Muscle Myosins

Parker and Peckham  |  Biophysical Reviews
Mutations in various myosin isoforms and their disease-causing effects – Read

The Tubulin Code in Microtubule Dynamics and Information Encoding

Roll-Mecak  |  Developmental Cell
Tubulin diversity and the mechanistic underpinnings of the tubulin code – Read

Our opinions are our own and do not represent the views or endorsement of the authors cited.

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