Journal Club

Critical Research Updates in the Cytoskeleton Field

Featured Articles

  • Zaferani et al⁠. PNAS, 2024
    The study by Zaferani et al. introduces a novel method for creating on-chip cytoskeletal circuits using branched microtubule networks. Inspired by axonal structures, the researchers combined microtubule branching nucleation pathways with microfabrication techniques to control the organization of microtubules within microfluidic devices. This approach enabled the construction of various microtubule architectures, including elements that mimic biological processes like transport and division. The platform offers potential applications in nanotechnology, such as efficient molecular transport and mechanical nanoactuators, by harnessing the dynamic nature of microtubules for controlled self-organization and growth. Read the article »
  • Chen et al⁠. EJMC 2024
    This study details the development of a new class of potent and highly selective G protein-coupled receptor kinase 5 (GRK5) inhibitors that form reversible covalent bonds with residue Cys474 in the GRK5 active site. These inhibitors show significant selectivity over GRK2, with one inhibitor displaying a GRK5 IC50 value of 10 nM and more than 100,000-fold selectivity. The study provides valuable insights into the interactions within the GRK5 active site that contribute to the high selectivity of these inhibitors, marking an important step in therapeutic GRK5 inhibitor development. Read the article »
  • Niedzialkowska et al⁠. JBC 2024
    Niedzialkowska et al. investigate the Chromosomal Passenger Complex (CPC) and its ability to generate parallel microtubule bundles in vitro. The research demonstrates that CPC condensates can generate microtubule bundles of uniform polarity (minus ends extended distally) when mixed with free tubulin monomer and GTP. This process involves liquid-liquid demixing and the specific binding of CPC to microtubules. The authors suggest this is the first complex demonstrated to organize microtubules in the opposite polarity of centrosomes and other MTOCs, providing insights into the role of CPC in cellular organization during mitosis. Read the article »
     

Quiz

Solve the Structure

 

Quiz

Leveraging oxygen to emit fluorescence, this protein serves as a crucial biological marker. Its gene has emerged as an indispensable instrument in the field of molecular and cellular biology. It enables scientists to precisely tag and monitor proteins, organelles, and cells within living organisms, facilitating real-time observation and study.

research paper

Notable Retractions

Dana-Farber retractions

Meet the blogger who spotted problems
in dozens of cancer papers
https://www.nature.com/  
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