Critical Research Updates in the Cytoskeleton Field
WAVE-Deficient Autoimmune Disorders, Wandering Monopolar Spindles, and a Guide to Selecting Cellular Actin Probes
Journal Club Picks
- Five patients with immunodeficiency harbor mutations in the WAVE regulatory complex.
Cook et al. | Lenardo Lab | Science
- Dilution of the cell cycle inhibitor Rb in growing cells triggers cell division to maintain cell size.
Zatulovskiy et al. | Skotheim Lab | Science
- Curved protofilaments at growing microtubule ends could explain kinetochore coupling.
Gudimchuk | McIntosh Lab | Nature Communications
- Microtubules help coordinate cytokinetic furrow formation in fission yeast.
Dundon and Pollard | Pollard Lab | Molecular Biology of the Cell
- Wandering monopolar spindles in flattened cells reveal spindle positioning mechanisms.
Dimitracopoulos et al. | Baum Lab | Current Biology
- XMAP215 and γ-tubulin have distinct modes of promoting microtubule nucleation.
King et al. | Davis Lab | Molecular Biology of the Cell
- A pliable tethering domain confers functional diversity to the microtubule motor KIF14.
Zhernov et al. | Lansky Lab | Current Biology
Structural Insights into Actin Filament Recognition by Commonly Used Cellular Actin Markers
Kumari et al. | The EMBO Journal
High resolution structures of commonly utilized actin markers – Read
Disease Mutations in Striated Muscle Myosins
Parker and Peckham | Biophysical Reviews
Mutations in various myosin isoforms and their disease-causing effects – Read
The Tubulin Code in Microtubule Dynamics and Information Encoding
Roll-Mecak | Developmental Cell
Tubulin diversity and the mechanistic underpinnings of the tubulin code – Read
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Journal Club Classics, Pure GTP-Microtubules, And Cytoskeletal Radiosensitizers Featured JCB65: Cytoskeleton Journal of Cell Biology This historical cytoskeleton collection commemorating the 65th anniversary of JCB features the seminal discoveries that disrupted the fields of tubulin and actin research. View the list of classic papers here. Journal Club Picks Dynamic microtubules deform giant unilamellar vesicles in
Expert Protocols, Microtubule Branching, and the Actin Interactome Must Read Cytoskeleton Dynamics: Methods and Protocols Helder Maiato (Ed.) This Methods in Molecular Biology series outlines a range of experimental approaches for studying actin and microtubule dynamics, and is sure to be an invaluable resource to new and seasoned researchers alike. View the Table of Contents.
Tubulin MRNA Degradation, Global Actin Flows, and Microtubule Plasticity Must Read TTC5 Mediates Autoregulation Of Tubulin Via mRNA Degradation Lin et al. | Hegde Lab | Science The soluble pool of tubulin monomers influences microtubule dynamics and microtubule-driven cellular processes including mitosis. As such, the cell imparts strict control over the concentration of soluble tubulin by selective degradation