Journal Club – June 2023
Prash Singh
June 1, 2023
Journal Club
Critical Research Updates in the Cytoskeleton Field
Journal Club – June 2023
Featured Articles
- Makaros et al. Mol. Cell. 2023
A study by Makaros et al. explores the role of C-terminal degrons in ubiquitin-independent proteasomal degradation. The study suggests that this mechanism may be crucial in coping with aberrant proteins accumulated in response to cellular stress. The conservation of C-degron-mediated degradation from bacteria to humans is also discussed, highlighting its evolutionary significance. Read the article. - Lawrence et al. J Cell Biol. 2023
The Zanic lab uses an array of nucleotides and analogs to demonstrate that CLASP1 dictates microtubule stability in a nucleotide-dependent manner. The authors conclude that CLASPs stabilize an intermediate state of microtubules as they transition from growth to shrinkage. Read the article.
Quiz
Solve the Structure
This enzyme is crucial for DNA replication and transcription by altering the degree of supercoiling in the DNA.
Notable Retractions
Combination of sphingosine-1-phosphate receptor 1 (S1PR1) agonist and antiviral drug: a potential therapy against pathogenic influenza virus.
Read the article.
Upcoming Grant Deadlines:
- NIH – R01 Research Grants, June 5th, 2023
- NIH – K Research Career Development, June 12th, 2023
- NIH – R15 Academic Research Enhancement Award (AREA), June 25th, 2023
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