WAVE-Deficient Autoimmune Disorders, Wandering Monopolar Spindles, and a Guide to Selecting Cellular Actin Probes

Journal Club Picks

• Five patients with immunodeficiency harbor mutations in the WAVE regulatory complex.
  Cook et al.  | Lenardo Lab  |  Science
• Dilution of the cell cycle inhibitor Rb in growing cells triggers cell division to maintain cell size.
  Zatulovskiy et al.  | Skotheim Lab  |  Science
• Curved protofilaments at growing microtubule ends could explain kinetochore coupling.
  Gudimchuk  | McIntosh Lab  |  Nature Communications
• Microtubules help coordinate cytokinetic furrow formation in fission yeast.
  Dundon and Pollard  | Pollard Lab  |  Molecular Biology of the Cell
• Wandering monopolar spindles in flattened cells reveal spindle positioning mechanisms.
  Dimitracopoulos et al.  | Baum Lab |  Current Biology
• XMAP215 and γ-tubulin have distinct modes of promoting microtubule nucleation.
  King et al.  | Davis Lab  |  Molecular Biology of the Cell
• A pliable tethering domain confers functional diversity to the microtubule motor KIF14.
  Zhernov et al.  | Lansky Lab  |  Current Biology

Resource

Structural Insights into Actin Filament Recognition by Commonly Used Cellular Actin Markers

Kumari et al.  |  The EMBO Journal
High resolution structures of commonly utilized actin markers – Read

Reviews

Disease Mutations in Striated Muscle Myosins

Parker and Peckham  |  Biophysical Reviews
Mutations in various myosin isoforms and their disease-causing effects – Read

The Tubulin Code in Microtubule Dynamics and Information Encoding

Roll-Mecak  |  Developmental Cell
Tubulin diversity and the mechanistic underpinnings of the tubulin code – Read

Our opinions are our own and do not represent the views or endorsement of the authors cited.