Journal Club – March 2020

Special Issue: Coronaviruses and the Cytoskeleton

Note from the Editor:  How does SARS-CoV-2 enter and navigate host cells? While this complex process remains elusive for a number of human betacoronaviruses, published studies on related viruses may serve as a springboard for understanding the infection and pathogenicity of the novel coronavirus underlying COVID-19.  We have distilled a portion of the current literature below to support you in combating what is now a global pandemic.

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Need a refresher on how viruses hijack cells?
Tubulins interact with porcine and human S proteins of the genus Alphacoronavirus and support successful assembly and release of infectious viral particles
Rüdiger et al.  |  Virology  |  2016

COVID-19 UPDATE: Scientists prioritized resolving the structure of the novel coronavirus spike protein and have achieved a 3.5 A resolution by cryo-EM. Link in Science

Effect of microtubule disruption on neuronal spread and replication of demyelinating and nondemyelinating strains of mouse hepatitis virus in vitro
Biswas and Sarma  |  Journal of Virology  |  2014
Ezrin interacts with the SARS coronavirus spike protein and restrains infection at the entry stage
Millet et al.  |  PLOS One  |  2012
Entry of human coronavirus NL63 into the cell
Milewska et al.  |  Journal of Virology  |  2018

COVID-19 UPDATE: Last week, scientists at Westlake University in Hangzhou, China, discovered that SARS-CoV-2 attaches to the same cell surface receptor as the NL63 virus, ACE2. Link in Science

Early events during human coronavirus OC43 entry to the cell
Owczarek et al.  |  Scientific Reports  |  2018
Interaction of the coronavirus infectious bronchitis virus membrane protein with β-actin and its implication in virion assembly and budding
Wang et al.  |  PLOS One  |  2009
Our opinions are our own and do not represent the views or endorsement of the authors cited.

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