Journal Club – February 2020

Journal Club Classics, Pure GTP-Microtubules, And Cytoskeletal Radiosensitizers


JCB65: Cytoskeleton

Journal of Cell Biology

Arp2/3 complexes
Arp2/3 complexes at actin branch points by Svitkina and Borisy, 1999

This historical cytoskeleton collection commemorating the 65th anniversary of JCB features the seminal discoveries that disrupted the fields of tubulin and actin research. View the list of classic papers here.

Journal Club Picks

  • Dynamic microtubules deform giant unilamellar vesicles in a minimal reconstituted system.
    Rodríguez-García et al.  |  Dogterom and Akhmanova Labs  |  Current Biology
  • EB proteins bind with high affinity along the entire length of pure GTP-microtubules.
    Roostalu et al.  |  Surrey Lab  |  eLife
  • The tail domain of kinesin-5 mediates microtubule sliding by interacting with the motor head.
    Bodrug et al.  |  Al-Bassam Lab  |  eLife
  • Kinetochore microtubules bridge with non-KMTs in large spindles lacking focused poles.
    O’Toole et al.  |  McIntosh Lab  |  Molecular Biology of the Cell
  • TPX2 pools tubulin subunits via phase separation to drive microtubule branching.
    King and Petry  |  Petry Lab  |  Nature Communications – Find us in the methods section!
  • A tubulin-specific chaperone promotes microtubule nucleation around chromatin.
    Métivier et al.  |  Giet Lab  |  bioRxiv – Find us in the methods section!
  • Oncogenic signaling enhances mitotic rounding to promote proliferation in confined spaces.
    Matthews et al.  |  Baum Lab  |  Developmental Cell
  • Minimal branched actin networks self-organize around and internalize endocytic pits.
    Akamatsu et al.  |  Rangamani and Drubin Labs  |  eLife
  • Encapsulated microtubule inhibitors localize to tumors prior to activation by irradiation.
    Gao et al.  |  Xie, Ma, and Kumar Labs  |  ACS Nano – Find us in the methods section!

Our opinions are our own and do not represent the views or endorsement of the authors cited.

Recent Newsletters

Journal Club Archives

Latest Newsletters from Journal Club

Journal Club – December 2019

Tubulin MRNA Degradation, Global Actin Flows, and Microtubule Plasticity Must Read TTC5 Mediates Autoregulation Of Tubulin Via mRNA Degradation Lin et al. | Hegde Lab | Science The soluble pool of tubulin monomers

Read More »

Journal Club – November 2019

The cell exhibits remarkable spatiotemporal control over its molecular constituents. Much of the cell’s internal organization was previously thought to arise from the inheritance of an already ordered state. However, in this study, Cheng and Ferrell perform an elegant experiment demonstrating the ability of cytoplasm to organize de novo based largely on microtubule polymerization dynamics and dynein-mediated transport.

Read More »

Journal Club – October 2019

Oligodendrocytes extend dozens of protrusions that envelop neighboring axons in insulating myelin sheaths. An intriguing population of lamellar microtubules spiral around the myelin sheath and are linked to diseases of hypomyelination, yet the intricacies of this complex microtubule architecture are unknown.

Read More »

Journal Club – September 2019

Tau Islands, Actin Locks, and Automated Kymograph Analysis Must Reads Cohesive Tau Islands Shield and Protect the Microtubule Lattice Tau, a microtubule-associated protein in the brain, is primarily recognized for

Read More »
Scroll to Top