Journal Club – February 2020

Journal Club Classics, Pure GTP-Microtubules, And Cytoskeletal Radiosensitizers


JCB65: Cytoskeleton

Journal of Cell Biology

Arp2/3 complexes
Arp2/3 complexes at actin branch points by Svitkina and Borisy, 1999

This historical cytoskeleton collection commemorating the 65th anniversary of JCB features the seminal discoveries that disrupted the fields of tubulin and actin research. View the list of classic papers here.

Journal Club Picks

  • Dynamic microtubules deform giant unilamellar vesicles in a minimal reconstituted system.
    Rodríguez-García et al.  |  Dogterom and Akhmanova Labs  |  Current Biology
  • EB proteins bind with high affinity along the entire length of pure GTP-microtubules.
    Roostalu et al.  |  Surrey Lab  |  eLife
  • The tail domain of kinesin-5 mediates microtubule sliding by interacting with the motor head.
    Bodrug et al.  |  Al-Bassam Lab  |  eLife
  • Kinetochore microtubules bridge with non-KMTs in large spindles lacking focused poles.
    O’Toole et al.  |  McIntosh Lab  |  Molecular Biology of the Cell
  • TPX2 pools tubulin subunits via phase separation to drive microtubule branching.
    King and Petry  |  Petry Lab  |  Nature Communications – Find us in the methods section!
  • A tubulin-specific chaperone promotes microtubule nucleation around chromatin.
    Métivier et al.  |  Giet Lab  |  bioRxiv – Find us in the methods section!
  • Oncogenic signaling enhances mitotic rounding to promote proliferation in confined spaces.
    Matthews et al.  |  Baum Lab  |  Developmental Cell
  • Minimal branched actin networks self-organize around and internalize endocytic pits.
    Akamatsu et al.  |  Rangamani and Drubin Labs  |  eLife
  • Encapsulated microtubule inhibitors localize to tumors prior to activation by irradiation.
    Gao et al.  |  Xie, Ma, and Kumar Labs  |  ACS Nano – Find us in the methods section!

Our opinions are our own and do not represent the views or endorsement of the authors cited.

Recent Newsletters

Journal Club Archives

Latest Newsletters from Journal Club

Journal Club – June 2023

Featured Articles

Makaros et al. Mol. Cell. 2023
A study by Makaros et al. explores the role of C-terminal degrons in ubiquitin-independent proteasomal degradation. The study suggests that this mechanism may be crucial in coping with aberrant proteins accumulated in response to cellular stress. The conservation of C-degron-mediated degradation from bacteria to humans is also discussed, highlighting its evolutionary significance.

Read More »

Journal Club – August 2020

WAVE-Deficient Autoimmune Disorders, Wandering Monopolar Spindles, and a Guide to Selecting Cellular Actin Probes Journal Club Picks Five patients with immunodeficiency harbor mutations in the WAVE regulatory complex.Cook et al.

Read More »

Journal Club – July 2020

Cytoskeleton Storms, Polarized Actin Cortex, and Protein Liquids Featured Membrane-Proximal F-Actin Restricts Local Membrane Protrusions and Directs Cell Migration Bisaria et al.  |  Meyer Lab  |  ScienceGlobal F-actin concentrations are

Read More »

Journal Club – May 2020

Spiraling Kinesins, Small Molecule Degraders, and Foldable Actin Networks Featured Kinesin-14 Motors Drive a Right-Handed Helical Motion of Antiparallel Microtubules Around Each Other Mitra et al.  |  Diez Lab  |

Read More »
Scroll to Top