Dear Researchers,
In light of the rapidly changing global health situation resulting from the COVID-19 virus, PurSolutions is committed to supporting researchers in their efforts to discover more about the virus and bring us closer to an effective vaccine or treatment.
As you may know, the structure of the COVID-19 spike protein was discovered a few days ago. It has been shown that coronavirus spike proteins interact with cytoskeleton filaments (i.e. microtubules and actin) for internalization into host cells – a critical step in viral pathogenesis. It has also been shown for some coronaviruses that targeting the cytoskeleton with tubulin or actin inhibitors reduces viral load.
- trial-size aliquots for testing
- large batches for lot consistency
- lot reservation
- ship now; pay later
- same-day shipping
Based on the number and nature of requests PurSolutions will make every effort to satisfy research priorities. To learn more or if you have any questions, please contact us at [email protected]
References:
- COVID-19 spike glycoprotein structure: https://www.ebi.ac.uk/pdbe/entry/emdb/EMD-21375
- Rüdiger, Anna-Theresa; Mayrhofer, Peter; et al. Tubulins interact with porcine and human S proteins of the genus Alphacoronavirus and support successful assembly and release of infectious viral particles. Virology 497, 185 (2016). https://doi.org/10.1016/j.virol.2016.07.022
- Szczepanski, A., Owczarek, K., Milewska, A. et al. Canine respiratory coronavirus employs caveolin-1-mediated pathway for internalization to HRT-18G cells. Vet Res 49, 55 (2018). https://doi.org/10.1186/s13567-018-0551-9
- Owczarek, K., Szczepanski, A., Milewska, A. et al. Early events during human coronavirus OC43 entry to the cell. Sci Rep 8, 7124 (2018). https://doi.org/10.1038/s41598-018-25640-0
- Milewska A, Nowak P, Owczarek K, et al. Entry of Human Coronavirus NL63 into the Cell. J Virol. 92 (3):e01933-17 (2018). https://doi.org/10.1128/JVI.01933-17