Category Archives: Archived Newsletter

Journal Club – September 2019

Tau Islands, Actin Locks, and Automated Kymograph Analysis   Must Reads Cohesive Tau Islands Shield and Protect the Microtubule Lattice Tau, a microtubule-associated protein in the brain, is primarily recognized for its role in neurodegenerative diseases. In fact, the term “tauopathy” was specifically coined to reference neuronal disorders pathologically defined by tau protein aggregates. But […]

Journal Club – August 2019

Light-Patterned Microtubule Asters, Nuclear Actin, And EB3-Islands   Must Read Controlling Organization And Forces In Active Matter Through Optically Defined Boundaries Ross et al. | Nature Cytoskeletal networks are dynamic, reconfigurable systems exquisitely tuned by the cell to perform a variety of functions. Reconstituting the diverse organization patterns of actin and microtubule networks in vitro […]

Journal Club – July 2019

Minus-End Growth, Reconstituted Spindle Midzones, and Contorted Microtubules   Must Read Patronin-Mediated Minus End Growth Is Required For Dendritic Microtubule Polarity Feng et al. | Journal of Cell Biology Microtubule minus-ends are often stably capped in cells, yielding the spotlight to their more dynamic plus-end counterparts. However, dendritic neurons present a compelling case for significant […]

Journal Club – June 2019

Spindle-F-Actin, Molecular Gearshifts, and Cytoplasmic Softening   Must Read Spindle-F-Actin Interactions in Mitotic Spindles in an Intact Vertebrate Epithelium Kita et al. | Molecular Biology of the Cell A compelling subject for striking microscopy images, microtubules have long been considered the major mechanical component of the mitotic spindle. But a long-standing question has been whether […]

Journal Club – May 2019

Spindle Heterogeneity, Microtubule Search and Capture, and Bulk Actin Waves   Must Read Mechanically Distinct Microtubule Arrays Determine the Length and Force Response of the Meiotic Spindle Takagi et al. | Developmental Cell The spindle is a remarkable macromolecular machine comprised of dynamic microtubules and associated factors. Given its critical job in driving chromosome segregation, […]

Journal Club – April 2019

Tubulin Beyond Microtubules, Inhibitable Kinesin-2, and Designer Organelles   Must Reads Tubulin mRNA Stability Is Sensitive To Change In Microtubule Dynamics Caused By Multiple Physiological And Toxic Cues Gasic, Boswell, and Mitchison | PLoS Biol. As the molecular building blocks of microtubules, alpha- and beta-tubulin heterodimers are subject to cellular surveillance. Studies in the 1980s […]

Journal Club – March 2019

Peeling Actomyosin Bundles, Tubulin Accretion, and Mapping the Primary Cilium   Must Reads Directionality Of Dynein Is Controlled By The Angle And Length Of Its Stalk Can et al. | Nature Dynein motors possess an uncanny ability to walk toward the microtubule minus end.  This minus end directionality is critical for retrograde intracellular transport (among other cellular […]