Featured Articles
Makaros et al. Mol. Cell. 2023
A study by Makaros et al. explores the role of C-terminal degrons in ubiquitin-independent proteasomal degradation. The study suggests that this mechanism may be crucial in coping with aberrant proteins accumulated in response to cellular stress. The conservation of C-degron-mediated degradation from bacteria to humans is also discussed, highlighting its evolutionary significance.
WAVE-Deficient Autoimmune Disorders, Wandering Monopolar Spindles, and a Guide to Selecting Cellular Actin Probes Journal Club Picks Five patients with immunodeficiency harbor mutations in the WAVE regulatory complex.Cook et al.  | Lenardo Lab  | Science Dilution of the cell cycle inhibitor Rb in growing cells triggers cell division to maintain cell size.Zatulovskiy et al.  | …
Cytoskeleton Storms, Polarized Actin Cortex, and Protein Liquids Featured Membrane-Proximal F-Actin Restricts Local Membrane Protrusions and Directs Cell Migration Bisaria et al. | Meyer Lab | ScienceGlobal F-actin concentrations are highest at the front of migrating cells where actin-based protrusions push the membrane forward. However, subpopulations of F-actin may be performing opposing functions to achieve …
Spiraling Kinesins, Small Molecule Degraders, and Foldable Actin Networks Featured Kinesin-14 Motors Drive a Right-Handed Helical Motion of Antiparallel Microtubules Around Each Other Mitra et al. |  Diez Lab |  Nature Communications Kinesin motor proteins that simultaneously bind two microtubules aid in remodeling cytoskeletal networks by sliding microtubules along one another. Microtubules can slide together …
Chromosome Bridges, DNA Webs, and Tubulin Citrullination Featured Mechanisms Generating Cancer Genome Complexity From A Single Cell Division Error Umbreit, Zhang et al. |  Pellman Lab |  Science Theories on the origin of cancer have historically centered on the gradual accumulation of deleterious genomic alterations over time. In recent years, however, researchers have discovered that …
Special Issue: Coronaviruses and the Cytoskeleton Note from the Editor: Â How does SARS-CoV-2 enter and navigate host cells? While this complex process remains elusive for a number of human betacoronaviruses, published studies on related viruses may serve as a springboard for understanding the infection and pathogenicity of the novel coronavirus underlying COVID-19. Â We have distilled …
Journal Club Classics, Pure GTP-Microtubules, And Cytoskeletal Radiosensitizers Featured JCB65: Cytoskeleton Journal of Cell Biology This historical cytoskeleton collection commemorating the 65th anniversary of JCB features the seminal discoveries that disrupted the fields of tubulin and actin research. View the list of classic papers here. Journal Club Picks Dynamic microtubules deform giant unilamellar vesicles in …
Expert Protocols, Microtubule Branching, and the Actin Interactome Must Read Cytoskeleton Dynamics: Methods and Protocols Helder Maiato (Ed.) This Methods in Molecular Biology series outlines a range of experimental approaches for studying actin and microtubule dynamics, and is sure to be an invaluable resource to new and seasoned researchers alike. View the Table of Contents. …
Tubulin MRNA Degradation, Global Actin Flows, and Microtubule Plasticity Must Read TTC5 Mediates Autoregulation Of Tubulin Via mRNA Degradation Lin et al. | Hegde Lab | Science The soluble pool of tubulin monomers influences microtubule dynamics and microtubule-driven cellular processes including mitosis. As such, the cell imparts strict control over the concentration of soluble tubulin by selective degradation …
The cell exhibits remarkable spatiotemporal control over its molecular constituents. Much of the cell’s internal organization was previously thought to arise from the inheritance of an already ordered state. However, in this study, Cheng and Ferrell perform an elegant experiment demonstrating the ability of cytoplasm to organize de novo based largely on microtubule polymerization dynamics and dynein-mediated transport.