Featured Articles
Makaros et al. Mol. Cell. 2023
A study by Makaros et al. explores the role of C-terminal degrons in ubiquitin-independent proteasomal degradation. The study suggests that this mechanism may be crucial in coping with aberrant proteins accumulated in response to cellular stress. The conservation of C-degron-mediated degradation from bacteria to humans is also discussed, highlighting its evolutionary significance.
Sabizabulin (VERU-111), an novel microtubule inhibitor, significantly reduced mortality in hospitalized patients with moderate to severe Covid-19 at high risk for acute respiratory distress syndrome and death according to an interim analysis from a randomized, global phase 3 clinical trial published this week in The New England Journal of Medicine Evidence.
After reviewing many exceptional applications, our panel has selected the recipient of the PurSolutions’ 2021 Reagent Scholarship: Mr. Narendran Annadurai Graduate Student Palacky University Olomouc Czech Republic Mr. Annadurai is pursuing the development of tau aggregation inhibitors for neurodegenerative diseases including Alzheimer’s disease. He will primarily be using in vitro aggregation assays and microscopy techniques. …
PurSolutions’ 2021 Reagent Scholarship Recipient Announcement Read More »
As discussed in our previous article back in March 2020, it has been shown that coronavirus spike proteins interact with cytoskeleton filaments (i.e. microtubules and actin) for internalization into host cells – a critical step in viral pathogenesis. It has also been shown for some coronaviruses that targeting the cytoskeleton with tubulin or actin inhibitors …
Small molecule tubulin inhibitor for COVID-19 treatment Read More »
Dear Researchers, In light of the rapidly changing global health situation resulting from the COVID-19 virus, PurSolutions is committed to supporting researchers in their efforts to discover more about the virus and bring us closer to an effective vaccine or treatment. As you may know, the structure of the COVID-19 spike protein was discovered a …
The cell exhibits remarkable spatiotemporal control over its molecular constituents. Much of the cell’s internal organization was previously thought to arise from the inheritance of an already ordered state. However, in this study, Cheng and Ferrell perform an elegant experiment demonstrating the ability of cytoplasm to organize de novo based largely on microtubule polymerization dynamics and dynein-mediated transport.
Oligodendrocytes extend dozens of protrusions that envelop neighboring axons in insulating myelin sheaths. An intriguing population of lamellar microtubules spiral around the myelin sheath and are linked to diseases of hypomyelination, yet the intricacies of this complex microtubule architecture are unknown.
Emma and Beattie attended and presented at the NSF SBIR/STTR Phase I Grantee Workshop held on March 19th-21st, 2018 in Arlington, VA. The workshop included featured speakers, entrepreneurial networking, presentations, and the Phase I “Beat-the-Odds Boot Camp”. The NSF Boot Camp provides an immersive experience that pushes companies to develop stronger business models, market strategies, …
PurSolutions, LLC opened its doors at the Cumberland Emerging Technologies (CET) Life Sciences Center in Nashville, TN. The CET Life Sciences Center is a business incubator facility that offers flexible wet lab, dry lab, and office space, as well as equipment and infrastructure to early-stage biomedical companies with a mission to help promising life sciences …
PurSolutions opens location in Nashville-based life sciences center Read More »
