Prash Singh

Co-Founder of PurSolutions, a biotech manufacturing startup that specializes in purifying cytoskeletal proteins. Co-Author of 6 Publications. Co-author: An alternative N-terminal fold of the intestine-specific annexin A13a induces dimerization and regulates membrane-binding Co-author; Multifunctional Pan-ebolavirus Antibody Recognizes a Site of Broad Vulnerability on the Ebolavirus Glycoprotein Co-author: Microtubule minus-end aster organization is driven by processive HSET-tubulin clusters Co-author: New crystal forms of the integral membrane Escherichia coli quinol:fumarate reductase suggest that ligands control domain movement Co-author: Structural basis of arrestin-3 activation and signaling Plasticity of the Quinone-Binding Site of the Complex II Homolog Quinol:Fumarate Reductase

Journal Club – February 2024

Featured Articles Zaferani et al⁠. PNAS, 2024 The study by Zaferani et al. introduces a novel method for creating on-chip cytoskeletal circuits using branched microtubule networks. Inspired by axonal structures, the researchers combined microtubule branching nucleation pathways with microfabrication techniques to control the organization of microtubules within microfluidic devices. This approach enabled the construction of […]

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Journal Club – September 2023

Featured Articles Eren et al⁠. Structure, 2023.HIV-1 Rev is a crucial protein that plays a role in transporting specific viral mRNAs from the nucleus to the cytoplasm, which is essential for the production of viral structural proteins. As it moves between the nucleus and cytoplasm, Revcollaborates with various host proteins, leveraging the cell’s machinery for

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Journal Club – July 2023

Featured Articles Guo et al. and Gouveia et al. Nature Comm, June 2023 Back-to-back papers by the Polenova and Petry labs provide valuable insights into the complex processes of microtubule nucleation and cell division, highlighting the roles of TPX2 and chromosomes in these processes. In the publication authored by Changmiao Guo, researchers investigate the role

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Journal Club – June 2023

Featured Articles

Makaros et al. Mol. Cell. 2023
A study by Makaros et al. explores the role of C-terminal degrons in ubiquitin-independent proteasomal degradation. The study suggests that this mechanism may be crucial in coping with aberrant proteins accumulated in response to cellular stress. The conservation of C-degron-mediated degradation from bacteria to humans is also discussed, highlighting its evolutionary significance.

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Microtubule-destabilizing SARS-CoV-2 Drug clears Phase III

Sabizabulin (VERU-111), an novel microtubule inhibitor, significantly reduced mortality in hospitalized patients with moderate to severe Covid-19 at high risk for acute respiratory distress syndrome and death according to an interim analysis from a randomized, global phase 3 clinical trial published this week in The New England Journal of Medicine Evidence.

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PurSolutions’ 2021 Reagent Scholarship Recipient Announcement

After reviewing many exceptional applications, our panel has selected the recipient of the PurSolutions’ 2021 Reagent Scholarship: Mr. Narendran Annadurai Graduate Student Palacky University Olomouc Czech Republic Mr. Annadurai is pursuing the development of tau aggregation inhibitors for neurodegenerative diseases including Alzheimer’s disease.  He will primarily be using in vitro aggregation assays and microscopy techniques.

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Small molecule tubulin inhibitor for COVID-19 treatment

As discussed in our previous article back in March 2020, it has been shown that coronavirus spike proteins interact with cytoskeleton filaments (i.e. microtubules and actin) for internalization into host cells – a critical step in viral pathogenesis. It has also been shown for some coronaviruses that targeting the cytoskeleton with tubulin or actin inhibitors

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COVID-19 Services – Expediting Research

Dear Researchers, In light of the rapidly changing global health situation resulting from the COVID-19 virus, PurSolutions is committed to supporting researchers in their efforts to discover more about the virus and bring us closer to an effective vaccine or treatment. As you may know, the structure of the COVID-19 spike protein was discovered a

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Journal Club – November 2019

The cell exhibits remarkable spatiotemporal control over its molecular constituents. Much of the cell’s internal organization was previously thought to arise from the inheritance of an already ordered state. However, in this study, Cheng and Ferrell perform an elegant experiment demonstrating the ability of cytoplasm to organize de novo based largely on microtubule polymerization dynamics and dynein-mediated transport.

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