WAVE-Deficient Autoimmune Disorders, Wandering Monopolar Spindles, and a Guide to Selecting Cellular Actin Probes Journal Club Picks Five patients with immunodeficiency harbor mutations in the WAVE regulatory complex.Cook et al. | Lenardo Lab | Science Dilution of the cell cycle inhibitor Rb in growing cells triggers cell division to maintain cell size.Zatulovskiy et al. | …
Cytoskeleton Storms, Polarized Actin Cortex, and Protein Liquids Featured Membrane-Proximal F-Actin Restricts Local Membrane Protrusions and Directs Cell Migration Bisaria et al. | Meyer Lab | ScienceGlobal F-actin concentrations are highest at the front of migrating cells where actin-based protrusions push the membrane forward. However, subpopulations of F-actin may be performing opposing functions to achieve …
Spiraling Kinesins, Small Molecule Degraders, and Foldable Actin Networks Featured Kinesin-14 Motors Drive a Right-Handed Helical Motion of Antiparallel Microtubules Around Each Other Mitra et al. | Diez Lab | Nature Communications Kinesin motor proteins that simultaneously bind two microtubules aid in remodeling cytoskeletal networks by sliding microtubules along one another. Microtubules can slide together …
Chromosome Bridges, DNA Webs, and Tubulin Citrullination Featured Mechanisms Generating Cancer Genome Complexity From A Single Cell Division Error Umbreit, Zhang et al. | Pellman Lab | Science Theories on the origin of cancer have historically centered on the gradual accumulation of deleterious genomic alterations over time. In recent years, however, researchers have discovered that …
Special Issue: Coronaviruses and the Cytoskeleton Note from the Editor: How does SARS-CoV-2 enter and navigate host cells? While this complex process remains elusive for a number of human betacoronaviruses, published studies on related viruses may serve as a springboard for understanding the infection and pathogenicity of the novel coronavirus underlying COVID-19. We have distilled …
Journal Club Classics, Pure GTP-Microtubules, And Cytoskeletal Radiosensitizers Featured JCB65: Cytoskeleton Journal of Cell Biology This historical cytoskeleton collection commemorating the 65th anniversary of JCB features the seminal discoveries that disrupted the fields of tubulin and actin research. View the list of classic papers here. Journal Club Picks Dynamic microtubules deform giant unilamellar vesicles in …
Expert Protocols, Microtubule Branching, and the Actin Interactome Must Read Cytoskeleton Dynamics: Methods and Protocols Helder Maiato (Ed.) This Methods in Molecular Biology series outlines a range of experimental approaches for studying actin and microtubule dynamics, and is sure to be an invaluable resource to new and seasoned researchers alike. View the Table of Contents. …
Tubulin MRNA Degradation, Global Actin Flows, and Microtubule Plasticity Must Read TTC5 Mediates Autoregulation Of Tubulin Via mRNA Degradation Lin et al. | Hegde Lab | Science The soluble pool of tubulin monomers influences microtubule dynamics and microtubule-driven cellular processes including mitosis. As such, the cell imparts strict control over the concentration of soluble tubulin by selective degradation …
Tau Islands, Actin Locks, and Automated Kymograph Analysis Must Reads Cohesive Tau Islands Shield and Protect the Microtubule Lattice Tau, a microtubule-associated protein in the brain, is primarily recognized for its role in neurodegenerative diseases. In fact, the term “tauopathy” was specifically coined to reference neuronal disorders pathologically defined by tau protein aggregates. But what …
Light-Patterned Microtubule Asters, Nuclear Actin, And EB3-Islands Must Read Controlling Organization And Forces In Active Matter Through Optically Defined Boundaries Ross et al. | Nature Cytoskeletal networks are dynamic, reconfigurable systems exquisitely tuned by the cell to perform a variety of functions. Reconstituting the diverse organization patterns of actin and microtubule networks in vitro has …
