Monthly Archives: July 2020

Small molecule tubulin inhibitor for COVID-19 treatment

As discussed in our previous article back in March 2020, it has been shown that coronavirus spike proteins interact with cytoskeleton filaments (i.e. microtubules and actin) for internalization into host cells – a critical step in viral pathogenesis. It has also been shown for some coronaviruses that targeting the cytoskeleton with tubulin or actin inhibitors […]

Journal Club – July 2020

Cytoskeleton Storms, Polarized Actin Cortex, and Protein Liquids   Featured Membrane-Proximal F-Actin Restricts Local Membrane Protrusions and Directs Cell Migration Bisaria et al.  |  Meyer Lab  |  Science Global F-actin concentrations are highest at the front of migrating cells where actin-based protrusions push the membrane forward. However, subpopulations of F-actin may be performing opposing functions […]